Gene editing plays a significant role in cancer therapy by allowing precise modifications to the DNA of cancer cells or immune cells, leading to targeted treatment approaches. Key roles include:
Targeted Therapy: Gene editing can specifically target and disrupt oncogenes (genes that can cause cancer when mutated or overexpressed) or repair tumor suppressor genes, potentially stopping cancer progression.
Immunotherapy Enhancement: Techniques like CRISPR can modify immune cells, such as T-cells, to better recognize and attack cancer cells. CAR-T cell therapy is an example where T-cells are engineered to express chimeric antigen receptors targeting cancer cells.
Resistance Mechanism Study: Gene editing allows researchers to study mechanisms of drug resistance in cancer cells, which can lead to the development of new therapies that overcome this resistance.
Personalized Medicine: By understanding the specific genetic mutations in an individual's cancer, gene editing can be used to create tailored therapies that are more effective and have fewer side effects.
Overall, gene editing holds great promise in advancing cancer treatment, making therapies more precise, effective, and personalized.
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